Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 3/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | AHCY | P23526 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.31 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592188 | 0.81 | FDPS (0.51) | FDPSHDAC1HDAC6LTA4HAHCY | |
| SCHEMBL4558644 | 0.77 | FDPS (0.54) | FDPSHDAC1HDAC6LTA4HAHCY | |
| SCHEMBL3976006 | 0.74 | FDPS (1.00) | FDPSHDAC1HDAC6LTA4HALDH1A1 | |
| SCHEMBL1079073 | 0.74 | FDPS (0.50) | FDPSHDAC1HDAC6LTA4HALDH1A1 | |
| SCHEMBL28615898 | 0.74 | AHCY (0.55) | FDPSHDAC1HDAC6LTA4HAHCY | |
| SCHEMBL3044440 | 0.72 | FDPS (0.63) | FDPSHDAC1HDAC6LTA4HCYP3A4 | |
| SCHEMBL8956114 | 0.71 | FDPS (0.56) | FDPSHDAC1HDAC6LTA4HALDH1A1 | |
| SCHEMBL3054581 | 0.70 | FGFR1 (0.60) | FDPSHDAC1HDAC6LTA4HALDH1A1 | |
| SCHEMBL1692456 | 0.70 | FDPS (0.56) | FDPSHDAC1HDAC6LTA4HALDH1A1 | |
| SCHEMBL8708627 | 0.69 | FDPS (0.59) | FDPSHDAC1HDAC6LTA4HCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0338887-B1 | Phosphonoalkylpurine derivatives | MERRELL DOW PHARMA (US) | 1993-12-08 | — | — | EP | disclosed |
| US-4988680-A | Phosphorylase inhibitors, immuno suppressants, parasiticides, antileukemia agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0338887-A1 | Phosphonoalkylpurine derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-10-25 | — | — | EP | disclosed |