Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004982 | 0.81 | AXL (0.40) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL456840 | 0.81 | IKBKB (0.43) | IKBKBMETAP2NR1H2NR1H3KDM4E | |
| SCHEMBL457788 | 0.77 | NPC1 (0.39) | SMN1; SMN2NPC1RAB9AIKBKBCHUK | |
| SCHEMBL792992 | 0.63 | NPC1 (1.00) | SMN1; SMN2NPC1RAB9AIKBKBCHUK | |
| SCHEMBL15299350 | 0.63 | HDAC3 (0.60) | SMN1; SMN2NPC1RAB9AIKBKBCHUK | |
| SCHEMBL23091872 | 0.63 | IKBKB (0.68) | SMN1; SMN2NPC1RAB9AIKBKBCHUK | |
| SCHEMBL3228033 | 0.63 | MEN1 (0.61) | SMN1; SMN2NPC1RAB9AIKBKBCHUK | |
| SCHEMBL11402365 | 0.61 | NPC1 (0.62) | SMN1; SMN2NPC1RAB9AIKBKBCHUK | |
| SCHEMBL5740333 | 0.60 | MAPT (0.54) | SMN1; SMN2NPC1RAB9AIKBKBCHUK | |
| SCHEMBL2614356 | 0.60 | IKBKB (0.50) | SMN1; SMN2NPC1RAB9AIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614053-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012033225-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-03-15 | — | — | WO | disclosed |