Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2766145 | 0.83 | RAB9A (0.71) | NPC1SMN1; SMN2RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL27741318 | 0.83 | NPC1 (0.70) | NPC1SMN1; SMN2RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL1160360 | 0.80 | NPC1 (0.67) | NPC1SMN1; SMN2RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL15908507 | 0.80 | NPC1 (0.67) | NPC1SMN1; SMN2RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL14097585 | 0.80 | L3MBTL1 (0.92) | NPC1SMN1; SMN2RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL2360295 | 0.80 | NPC1 (0.67) | NPC1SMN1; SMN2RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL16115554 | 0.79 | NPC1 (0.66) | NPC1SMN1; SMN2RAB9AL3MBTL1ALK | |
| SCHEMBL21198241 | 0.79 | SMN1; SMN2 (0.66) | NPC1SMN1; SMN2RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL427627 | 0.79 | L3MBTL1 (1.00) | NPC1SMN1; SMN2RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL13363876 | 0.78 | CYP1A2 (0.66) | NPC1SMN1; SMN2RAB9AL3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113354635-B | Pyrrolidine integrin regulator and application thereof | 清药同创(北京)药物研发中心有限公司 | 2023-04-18 | — | — | CN | disclosed |
| EP-3950678-A1 | AROMATIC AMINE COMPOUND AND USE THEREOF IN PREPARATION OF AR AND BRD4 DUAL INHIBITORS AND REGULATORS | Hinova Pharmaceuticals Inc. (CN) | 2022-02-09 | — | — | EP | disclosed |
| CN-113354635-A | Pyrrolidine integrin regulator and application thereof | 清药同创(北京)药物研发中心有限公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-111793031-B | Aromatic amine compound and application thereof in preparation of AR and BRD4 dual inhibitor and regulator | 海创药业股份有限公司 | 2021-06-22 | — | — | CN | disclosed |
| CN-111793031-A | Aromatic amine compound and application thereof in preparation of AR and BRD4 dual inhibitor and regulator | 成都海创药业有限公司 | 2020-10-20 | — | — | CN | disclosed |
| WO-2020200209-A1 | AROMATIC AMINE COMPOUND AND USE THEREOF IN PREPARATION OF AR AND BRD4 DUAL INHIBITORS AND REGULATORS | 成都海创药业有限公司 | 2020-10-08 | — | — | WO | disclosed |
| EP-2225211-B1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | DU PONT (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2616443-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | Exelixis, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| US-20130165440-A1 | JAK1 Inhibitors | EXELIXIS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165440-A1 | JAK1 Inhibitors | EXELIXIS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20120095044-A1 | TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION | Sanford-Burnham Medical Research Institute California | 2012-04-19 | — | — | US | disclosed |
| WO-2012037132-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037132-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |
| US-8119693-B2 | Tissue non-specific alkaline phosphatase inhibitors and uses thereof for treating vascular calcification | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-02-21 | — | — | US | disclosed |
| US-20100267561-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | E. I. DU PONT DE NEMOURS AND COMPANY | 2010-10-21 | — | — | US | disclosed |
| EP-2225211-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | E. I. du Pont de Nemours and Company (US) | 2010-09-08 | — | — | EP | disclosed |
| WO-2010046780-A2 | ANTI VIRAL COMPOUNDS | INSTITUT PASTEUR KOREA (KR) | 2010-04-29 | — | — | WO | disclosed |
| WO-2009086041-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-07-09 | — | — | WO | disclosed |
| US-20090156560-A1 | TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2009-06-18 | — | — | US | disclosed |
| WO-2009017863-A2 | TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095044-A1 | TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION | ALPL, CNDP2, ALPI | NPC1 2886/4885SMN1; SMN2 4792/4885RAB9A 3655/4885 |
| US-20090156560-A1 | TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION | ALPL, CNDP2, ALPI | NPC1 2886/4885SMN1; SMN2 4792/4885RAB9A 3655/4885 |
| US-20130165440-A1 | JAK1 Inhibitors | JAK1, JAK2, JAK3 | NPC1 2912/4885SMN1; SMN2 3265/4885RAB9A 1911/4885 |
| US-20100267561-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | CYP1A1, CYP1B1, CBR3 | NPC1 4290/4885SMN1; SMN2 4277/4885RAB9A 3035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.