Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | RPA1 | P27694 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455865 | 0.81 | SMN1; SMN2 (0.46) | IKBKBLMNANR1H2METAP2KDM4E | |
| SCHEMBL455592 | 0.80 | AKT2 (0.42) | NR1H2ALPLPOLBDCUN1D1KDM4E | |
| SCHEMBL458885 | 0.77 | LMNA (0.40) | IKBKBMAP3K14TRPM8GFERLMNA | |
| SCHEMBL4637112 | 0.70 | KMT2A (0.46) | LMNANR1H2ALPLPOLBNOTUM | |
| SCHEMBL3940018 | 0.65 | NR1H4 (0.42) | NOTUMKDM4E | |
| SCHEMBL27492602 | 0.64 | NOTUM (0.39) | IKBKBMAP3K14TRPM8LMNAMKNK1 | |
| SCHEMBL3632831 | 0.63 | BTK (0.46) | LMNATDP1ALPLPOLBMETAP2 | |
| SCHEMBL24962586 | 0.63 | IKBKB (0.68) | IKBKBMAP3K14LMNATDP1MKNK1 | |
| SCHEMBL3070625 | 0.63 | TRPM8 (0.62) | IKBKBMAP3K14TRPM8TDP1MKNK1 | |
| SCHEMBL15121080 | 0.63 | ALPL (0.61) | IKBKBMAP3K14TRPM8NR1H2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614053-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012033225-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-03-15 | — | — | WO | disclosed |