Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL458788 | 0.82 | BTK (0.36) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL455865 | 0.77 | SMN1; SMN2 (0.46) | NPC1RAB9ASMN1; SMN2IKBKBCHUK | |
| SCHEMBL4637026 | 0.67 | NR1H2 (0.40) | NPC1RAB9ASMN1; SMN2MEN1USP2 | |
| SCHEMBL21198241 | 0.63 | SMN1; SMN2 (0.66) | NPC1RAB9ASMN1; SMN2MEN1USP2 | |
| SCHEMBL14790649 | 0.61 | ERBB2 (0.50) | NPC1RAB9ASMN1; SMN2IKBKBCHUK | |
| SCHEMBL27519570 | 0.61 | METAP2 (0.38) | NPC1RAB9ASMN1; SMN2IKBKBCHUK | |
| SCHEMBL20616131 | 0.60 | HRH1 (0.46) | NPC1RAB9ASMN1; SMN2MAPK1NFKB1 | |
| SCHEMBL2479806 | 0.60 | MAPK1 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1 | |
| Propane SCHEMBL27739979 | 0.59 | CYP2A6 (0.67) | SMN1; SMN2ALDH1A1PLCG1MAPK1GAA | |
| SCHEMBL456840 | 0.58 | IKBKB (0.43) | IKBKBMETAP2NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614053-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012033225-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-03-15 | — | — | WO | disclosed |