Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | RHEB | Q15382 | 2/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 2/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21824161 | 0.73 | GABRA1 (0.36) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL3102877 | 0.72 | NOTUM (0.43) | CA12CA1CA2CA9CA14 | |
| SCHEMBL940060 | 0.71 | BRD4 (0.37) | LMNA | |
| SCHEMBL22778008 | 0.69 | HCAR3 (0.41) | LMNA | |
| SCHEMBL29714377 | 0.69 | HCAR3 (0.41) | LMNA | |
| SCHEMBL15566143 | 0.68 | L3MBTL1 (0.40) | HSD17B10LMNA | |
| SCHEMBL1132147 | 0.67 | CHRNA1 (0.51) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL17495245 | 0.67 | CA12 (0.46) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL2609133 | 0.67 | CA12 (0.50) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL10776576 | 0.67 | ESR1 (0.55) | GABRG2GABRB3GABRA1GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |