Chloralin

Chloralin

SCHEMBL455937

O=[N+]([O-])c1cc(C(F)(F)F)cc([N+](=O)[O-])c1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 1.00
ALDH1A1 P00352 3/20 1.00
TSHR P16473 2/20 1.00
TDP1 Q9NUW8 2/20 1.00
HPGD P15428 1/20 1.00
ALOX15 P16050 1/20 1.00
HIF1A Q16665 1/20 1.00
TXNRD1 Q16881 1/20 1.00
TXNRD3 Q86VQ6 1/20 1.00
TXNRD2 Q9NNW7 1/20 1.00
PTPN5 P54829 1/20 0.54
MAPK1 P28482 3/20 0.51
VCAM1 P19320 1/20 0.50
GPR35 Q9HC97 1/20 0.47
MAPT P10636 4/20 0.46
POLB P06746 2/20 0.46
LMNA P02545 1/20 0.46
GAA P10253 1/20 0.46
PLK1 P53350 1/20 0.46
KDM4E B2RXH2 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7819749 0.90 ALDH1A1 (0.82) CYP3A4ALDH1A1TSHRTDP1HPGD
Chloralin SCHEMBL28889062 0.89 TSHR (0.80) CYP3A4ALDH1A1TSHRTDP1HPGD
SCHEMBL10414958 0.89 CYP3A4 (0.79) CYP3A4ALDH1A1TSHRTDP1HPGD
SCHEMBL11343876 0.89 ALDH1A1 (0.79) CYP3A4ALDH1A1TSHRTDP1HPGD
SCHEMBL10862632 0.87 ALDH1A1 (0.77) CYP3A4ALDH1A1TSHRTDP1HPGD
SCHEMBL17680884 0.87 CYP3A4 (0.77) CYP3A4ALDH1A1TSHRTDP1HPGD
SCHEMBL9649686 0.87 CYP3A4 (0.77) CYP3A4ALDH1A1TSHRTDP1HPGD
SCHEMBL13955634 0.84 CYP3A4 (0.72) CYP3A4ALDH1A1TSHRTDP1HPGD
SCHEMBL8431056 0.83 CYP3A4 (0.70) CYP3A4ALDH1A1TSHRTDP1HPGD
SCHEMBL1202928 0.83 TDP1 (0.70) CYP3A4ALDH1A1TSHRTDP1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 490 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118702576-A Process for improving yield of 4-chloro-3, 5-dinitrobenzotrifluoride 福建康峰新材料有限公司 2024-09-27 CN claimed
CN-118647270-A Novel derivatives of non-coding amino acids and their use as herbicides 福提费斯特有限公司 2024-09-13 CN claimed
CN-118184577-B Phenyl ether meta-amide compound and application thereof 山东省农药科学研究院 2024-07-23 CN claimed
CN-118307414-A Synthesis method of trifluralin 江西巍华化学有限公司 2024-07-09 CN claimed
CN-118271176-A Preparation method of 4-chloro-3, 5-dinitrobenzotrifluoride 江西巍华化学有限公司 2024-07-02 CN claimed
CN-118184577-A Phenyl ether meta-amide compound and application thereof 山东省农药科学研究院 2024-06-14 CN claimed
CN-117902988-A Preparation method of 2, 6-dinitro-N, N-diethanol-4-trifluoro toluidine 福建康峰新材料有限公司 2024-04-19 CN claimed
CN-114805087-B Method for preparing trifluralin by utilizing micro-reaction system 山东道可化学有限公司 2023-12-26 CN claimed
CN-115057780-B Preparation method and device of 3, 5-dinitro-4-chlorotrifluoromethane 山东道可化学有限公司 2023-02-03 CN claimed
CN-113214087-B Preparation method and application of 4-chloro-3, 5-dinitro-benzotrifluoride 山东科加工业技术研究院有限公司 2022-11-01 CN claimed
EP-0022241-B1 PROCESS FOR THE REMOVAL OF NITROUSING AGENT(S) FROM NITRATED AROMATIC COMPOUNDS HOECHST AKTIENGESELLSCHAFT (DE) 1982-11-10 EP claimed
US-4338473-A Method for removing nitrosation agent(s) from a nitrated aromatic compound HOECHST AKTIENGESELLSCHAFT (DE) 1982-07-06 US claimed
US-4335260-A Process for the preparation of N-di-n-propyl-2,6-dinitro-4-trifluoromethylaniline having a low content of nitrosamines MONTEDISON S.P.A. (IT) 1982-06-15 US claimed
EP-0040762-A1 Process for the preparation of N-di-n-propyl-2,6-dinitro-4-trifluoromethylaniline with low content of nitrosamines Montedison S.p.A. (IT) 1981-12-02 EP claimed
EP-0022241-A1 Process for the removal of nitrousing agent(s) from nitrated aromatic compounds HOECHST AKTIENGESELLSCHAFT (DE) 1981-01-14 EP claimed
EP-0019281-A2 Process for the removal of nitrozation agents from nitrated aromatic compounds HOECHST AKTIENGESELLSCHAFT (DE) 1980-11-26 EP claimed
US-4187096-A FUNGICIDES, INSECTICIDES, CYCLIZATION THE ANSUL COMPANY (US) 1980-02-05 US claimed
US-4175186-A CYCLIZATION OF A NITROHALOBENZENE COMPOUND WITH A DIALKYDITHIOCARBAMIC ACID THE ANSUL COMPANY (US) 1979-11-20 US claimed
US-4120905-A FROM 1-CHLORO-2.6-DINITRO-4-(TRIFLUOROMETHYL)BENZENE, BUBBLING WITH GAS ADN BASIC SOLUTION ELI LILLY AND COMPANY (US) 1978-10-17 US claimed
US-4096195-A Cyclic two-stage nitration process for preparing 4-chloro-3,5-dinitrobenzotrifluoride from 4-chlorobenzotrifluoride GAF CORPORATION (US) 1978-06-20 US claimed