Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | CNR1 | P21554 | 1/20 | 0.71 |
| ▸ | CNR2 | P34972 | 1/20 | 0.71 |
| ▸ | NAMPT | P43490 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.60 |
| ▸ | HPGDS | O60760 | 1/20 | 0.60 |
| ▸ | FAAH | O00519 | 1/20 | 0.59 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.59 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.59 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.59 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.59 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.59 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.59 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14306236 | 0.97 | MAPT (0.69) | MAPTCNR1CNR2NAMPTKMT2A | |
| SCHEMBL6153200 | 0.95 | KMT2A (0.69) | MAPTCNR1CNR2NAMPTKMT2A | |
| SCHEMBL10253402 | 0.90 | CNR2 (0.88) | MAPTCNR1CNR2NAMPTKMT2A | |
| SCHEMBL2097739 | 0.87 | MAPT (0.59) | MAPTCNR1CNR2NAMPTKMT2A | |
| SCHEMBL3072567 | 0.87 | MAPT (0.59) | MAPTCNR1CNR2NAMPTKMT2A | |
| SCHEMBL10258124 | 0.87 | AKR1C3 (0.62) | MAPTCNR1CNR2KMT2AKDM4E | |
| SCHEMBL10253411 | 0.87 | CNR2 (0.78) | MAPTCNR1CNR2NAMPTKMT2A | |
| SCHEMBL15134839 | 0.86 | EPHX2 (0.69) | MAPTCNR1CNR2NAMPTKMT2A | |
| SCHEMBL28363944 | 0.86 | SMN1; SMN2 (0.70) | MAPTCNR1CNR2NAMPTKMT2A | |
| SCHEMBL6764534 | 0.86 | NAMPT (0.61) | MAPTCNR1CNR2NAMPTTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137549-A1 | Novel compounds useful for the treatment of degenerative & inflamatory diseases | GALAPAGOS NV (BE) | 2009-05-28 | — | — | US | disclosed |
| WO-2008055959-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137549-A1 | Novel compounds useful for the treatment of degenerative & inflamatory diseases | PDE4A, PDE7B, PDE4B | MAPT 4149/4885CNR1 2794/4885CNR2 3362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.