Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331319 | 0.80 | OPRM1 (0.61) | OPRM1HSD17B10CYP3A4SIGMAR1OPRL1 | |
| SCHEMBL5671761 | 0.79 | OPRM1 (0.53) | OPRM1HSD17B10CYP3A4SIGMAR1OPRL1 | |
| SCHEMBL5674633 | 0.77 | OPRM1 (0.57) | OPRM1HSD17B10CYP3A4SIGMAR1OPRL1 | |
| SCHEMBL17140511 | 0.74 | OPRM1 (0.53) | OPRM1HSD17B10CYP3A4SIGMAR1OPRL1 | |
| SCHEMBL12022949 | 0.74 | OPRM1 (0.69) | OPRM1HSD17B10CYP3A4SIGMAR1OPRL1 | |
| SCHEMBL24712978 | 0.71 | OPRM1 (0.65) | OPRM1HSD17B10CYP3A4SIGMAR1OPRL1 | |
| SCHEMBL1587072 | 0.71 | OPRM1 (0.65) | OPRM1HSD17B10CYP3A4SIGMAR1OPRL1 | |
| SCHEMBL62966 | 0.71 | OPRM1 (0.65) | OPRM1HSD17B10CYP3A4SIGMAR1OPRL1 | |
| SCHEMBL8894213 | 0.71 | OPRM1 (0.50) | OPRM1HSD17B10CYP3A4SIGMAR1OPRL1 | |
| SCHEMBL9233113 | 0.71 | CHRM2 (0.50) | OPRM1OPRL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176789-A1 | Diazaspirodecane orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-07-09 | — | — | US | disclosed |
| US-20090176789-A1 | Diazaspirodecane orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-07-09 | — | — | US | disclosed |
| US-20090176789-A1 | Diazaspirodecane orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-07-09 | — | — | US | disclosed |
| EP-1922071-A2 | DIAZASPIRODECANE OREXIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007025069-A2 | DIAZASPIRODECANE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2007025069-A2 | DIAZASPIRODECANE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176789-A1 | Diazaspirodecane orexin receptor antagonists | HCRTR2, HCRTR1, OXTR | OPRM1 294/4885HSD17B10 1262/4885CYP3A4 3650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.