Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 5/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9228402 | 0.93 | ACHE (0.46) | CHRM2CHRM3ACHEOPRM1CYP2D6 | |
| SCHEMBL9234493 | 0.86 | CYP2D6 (0.48) | CHRM2CHRM3ACHECYP2D6ALDH1A1 | |
| SCHEMBL9233255 | 0.84 | CHRM2 (0.52) | CHRM2CHRM3ACHEOPRM1CYP2D6 | |
| SCHEMBL2331319 | 0.83 | OPRM1 (0.61) | ACHEOPRM1CYP2D6ALDH1A1OPRL1 | |
| SCHEMBL9232468 | 0.82 | CHRM2 (0.53) | CHRM2CHRM3ACHEOPRM1ALDH1A1 | |
| SCHEMBL9228793 | 0.80 | CHRM2 (0.47) | CHRM2CHRM3ACHEOPRM1CYP2D6 | |
| SCHEMBL5674633 | 0.79 | OPRM1 (0.57) | OPRM1CYP2D6ALDH1A1OPRL1 | |
| SCHEMBL17140511 | 0.79 | OPRM1 (0.53) | ACHEOPRM1CYP2D6ALDH1A1OPRL1 | |
| SCHEMBL6045574 | 0.76 | OPRM1 (0.54) | ACHEOPRM1OPRL1 | |
| SCHEMBL8894213 | 0.76 | OPRM1 (0.50) | CHRM2CHRM3ACHEOPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677522-A1 | 8-METHOXYQUINOLONECARBOXYLIC ACID DERIVATIVE | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1995-10-18 | — | — | EP | disclosed |