Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31532384 | 0.78 | LMNA (0.40) | TGFBR1GAAPOLBLMNA | |
| SCHEMBL21780683 | 0.76 | CRHR1 (0.57) | CRHR1GRM2TGFBR1GAAPOLB | |
| SCHEMBL21768453 | 0.76 | GRM2 (0.46) | CRHR1GRM2CNR2TGFBR1GAA | |
| SCHEMBL20283020 | 0.75 | CNR1 (0.33) | GRM2CNR2CNR1POLBLMNA | |
| SCHEMBL2686133 | 0.74 | CRHR1 (0.39) | CRHR1GRM2CNR2TGFBR1GAA | |
| SCHEMBL18695205 | 0.74 | TP53 (0.41) | GAAPOLBLMNA | |
| SCHEMBL25370431 | 0.74 | CRHR1 (0.42) | CRHR1GRM2CNR2TGFBR1GAA | |
| SCHEMBL27783208 | 0.73 | LMNA (0.40) | CNR2CNR1LMNA | |
| SCHEMBL19105610 | 0.73 | CRHR1 (0.41) | CRHR1GRM2CNR2TGFBR1GAA | |
| SCHEMBL18695253 | 0.72 | TP53 (0.45) | CNR2GAACNR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638034-A1 | SUBSTITUTED HETEROAROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062462-A1 | SUBSTITUTED HETEROAROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2012-05-18 | — | — | WO | disclosed |