Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18695186 | 0.92 | L3MBTL1 (0.43) | TP53L3MBTL1TLR7LMNAALDH1A1 | |
| SCHEMBL18695205 | 0.85 | TP53 (0.41) | TP53L3MBTL1LMNAALDH1A1HPGD | |
| SCHEMBL27783208 | 0.81 | LMNA (0.40) | TP53L3MBTL1CNR2CNR1LMNA | |
| SCHEMBL31532384 | 0.80 | LMNA (0.40) | TP53L3MBTL1LMNAALDH1A1HPGD | |
| SCHEMBL17177770 | 0.78 | TP53 (0.59) | TP53L3MBTL1LMNAALDH1A1HPGD | |
| SCHEMBL18695267 | 0.77 | ALDH1A1 (0.35) | CNR2CNR1ALDH1A1MPO | |
| SCHEMBL17196467 | 0.76 | L3MBTL1 (0.44) | TP53L3MBTL1CNR2CNR1TLR7 | |
| SCHEMBL18811869 | 0.76 | CNR2 (0.50) | TP53L3MBTL1CNR2CNR1TLR7 | |
| SCHEMBL22637870 | 0.75 | TP53 (0.50) | TP53L3MBTL1CNR2CNR1LMNA | |
| SCHEMBL18695215 | 0.75 | L3MBTL1 (0.46) | TP53L3MBTL1CNR2CNR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10100041-B2 | Pyrazolyl substituted tetrahydropyranylsulfones | Grünenthal GmbH (DE) | 2018-10-16 | — | — | US | disclosed |
| CN-108473480-A | The oxinane sulfone of pyrazolyl substitution | 格吕伦塔尔有限公司 | 2018-08-31 | — | — | CN | disclosed |
| US-20170101398-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
| US-20170101398-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
| WO-2017059966-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170101398-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | TRPV1, CACNA1G, CACNA1B | TP53 3998/4885L3MBTL1 4056/4885CNR2 163/4885 |
| US-10100041-B2 | Pyrazolyl substituted tetrahydropyranylsulfones | TRPV1, CACNA1G, CACNA1B | TP53 3998/4885L3MBTL1 4056/4885CNR2 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.