Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | BPTF | Q12830 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255378 | 0.87 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1BPTFSLC6A3DRD2 | |
| SCHEMBL30167608 | 0.87 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1BPTFSLC6A3DRD2 | |
| SCHEMBL3159432 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1BPTFSLC6A3DRD2 | |
| SCHEMBL29709387 | 0.84 | BPTF (0.46) | SMN1; SMN2ALDH1A1BPTFALOX5NPC1 | |
| SCHEMBL30407553 | 0.83 | BPTF (0.51) | SMN1; SMN2ALDH1A1BPTFALOX5NPC1 | |
| SCHEMBL20699709 | 0.78 | BPTF (0.54) | SMN1; SMN2ALDH1A1BPTFALOX5MAPT | |
| SCHEMBL10373948 | 0.78 | BPTF (0.54) | SMN1; SMN2ALDH1A1BPTFALOX5MAPT | |
| SCHEMBL27955969 | 0.77 | KDM4E (0.47) | SMN1; SMN2ALDH1A1BPTFDRD2DRD3 | |
| SCHEMBL4071905 | 0.74 | BPTF (0.48) | SMN1; SMN2ALDH1A1BPTFDRD2DRD3 | |
| SCHEMBL4791897 | 0.72 | BPTF (0.49) | SMN1; SMN2ALDH1A1BPTFALOX5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034095-A1 | COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | disclosed |