Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 8/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GABRE | P78334 | 1/20 | 0.32 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26104805 | 0.77 | GABRA1 (0.37) | GABRG2GABRB3GABRA5GABRA1CNR1 | |
| SCHEMBL451720 | 0.77 | GABRA1 (0.34) | GABRG2GABRB3GABRA5GABRA1CNR1 | |
| SCHEMBL452993 | 0.69 | CA9 (0.35) | MAPTKMT2A | |
| SCHEMBL21062880 | 0.68 | KDM4E (0.47) | MAPTLMNAKMT2A | |
| SCHEMBL14743139 | 0.67 | LMNA (0.40) | GABRG2GABRB3GABRA5GABRA1CNR1 | |
| SCHEMBL16241555 | 0.66 | S1PR2 (0.40) | GABRG2GABRB3GABRA5GABRA1CNR1 | |
| SCHEMBL2568941 | 0.65 | NQO2 (0.37) | SYK | |
| SCHEMBL38663056 | 0.63 | MAPT (0.35) | MAPTLMNAKMT2A | |
| SCHEMBL16099451 | 0.63 | MLLT1 (0.34) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL454321 | 0.62 | MAOB (0.35) | GABRG2GABRB3GABRA5GABRA1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9238647-B2 | P2X3 receptor antagonists for treatment of pain | MERCK SHARP & DOHME CORP. (US) | 2016-01-19 | — | — | US | disclosed |
| US-20120064181-A1 | P2X3 Receptor Antagonists for Treatment of Pain | MERCK SHARP & DOHME LLC | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064181-A1 | P2X3 Receptor Antagonists for Treatment of Pain | P2RX3, P2RX1, P2RX2 | GABRG2 516/4885GABRB3 144/4885GABRA5 303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.