Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 7/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 5/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2191733 | 0.97 | HTR7 (0.50) | HTR7DRD2DRD4HTR1AHTR2A | |
| SCHEMBL2195868 | 0.97 | HTR7 (0.47) | HTR7DRD2DRD4HTR1AHTR2A | |
| SCHEMBL2196037 | 0.95 | HTR7 (0.45) | HTR7DRD2DRD4HTR1AHTR2A | |
| SCHEMBL1253411 | 0.90 | HTR7 (0.45) | HTR7DRD2HTR1AHTR2AHTR6 | |
| SCHEMBL3258946 | 0.88 | KDM4E (0.47) | DRD2DRD4HTR1AHTR2AHTR6 | |
| SCHEMBL4057154 | 0.87 | KDM4E (0.47) | HTR7DRD2DRD4HTR1AHTR2A | |
| SCHEMBL4561888 | 0.86 | HRH3 (0.40) | HTR7DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL1254641 | 0.86 | HTR7 (0.66) | HTR7DRD2HTR1AHTR2AHTR6 | |
| SCHEMBL1254473 | 0.86 | HTR7 (0.63) | HTR7DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL3426445 | 0.86 | HTR7 (0.44) | HTR7DRD2HTR1AHTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1715921-A4 | TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS | ABRAXIS BIOSCIENCE INC (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1715921-A2 | TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS | Cenomed, Inc. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005030148-A2 | TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS | CENOMED, INC. (US) | 2005-04-07 | — | — | WO | disclosed |