Ly-255283

Ly-255283

SCHEMBL4562255

CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 16/20 0.69
LTB4R Q15722 5/20 0.69
LTB4R2 Q9NPC1 5/20 0.69
MEN1 O00255 1/20 0.69
ALDH1A1 P00352 1/20 0.69
CYP3A4 P08684 1/20 0.69
THRB P10828 1/20 0.69
HPGD P15428 1/20 0.69
ALOX15 P16050 1/20 0.69
TSHR P16473 1/20 0.69
HTR2B P41595 1/20 0.69
KMT2A Q03164 1/20 0.69
HSD17B10 Q99714 1/20 0.69
SIGMAR1 Q99720 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9417960 0.96 NR1H4 (0.63) NR1H4LTB4RLTB4R2MEN1ALDH1A1
SCHEMBL8610596 0.89 NR1H4 (0.67) NR1H4LTB4RLTB4R2MEN1ALDH1A1
Ly-255283 SCHEMBL7749547 0.82 NR1H4 (1.00) NR1H4LTB4RLTB4R2MEN1ALDH1A1
SCHEMBL9417932 0.81 NR1H4 (0.57) NR1H4LTB4RLTB4R2MEN1ALDH1A1
SCHEMBL7646400 0.81 LTB4R (0.71) NR1H4LTB4RLTB4R2
SCHEMBL10346817 0.80 NR1H4 (0.66) NR1H4LTB4RLTB4R2MEN1ALDH1A1
SCHEMBL9417801 0.80 LTB4R (0.56) NR1H4LTB4RLTB4R2MEN1ALDH1A1
SCHEMBL7699998 0.80 NR1H4 (0.48) NR1H4LTB4RLTB4R2MEN1ALDH1A1
SCHEMBL7646883 0.79 LTB4R (0.73) NR1H4LTB4RLTB4R2
Bicarbonate SCHEMBL10346826 0.78 NR1H4 (0.64) NR1H4LTB4RLTB4R2MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4731002-A2 SYSTEMS FOR PRODUCTION OF PRODUCTS TO PROMOTE NITROGEN USE EFFICIENCY IN PLANTS Tenfold Technologies, LLC (US) 2026-04-29 EP claimed
WO-2024263793-A2 SYSTEMS FOR PRODUCTION OF PRODUCTS TO PROMOTE NITROGEN USE EFFICIENCY IN PLANTS Tenfold Technologies, LLC (US) 2024-12-26 WO claimed
US-20170333516-A1 PREVENTIVE OR THERAPEUTIC AGENT FOR AGE-RELATED MACULAR DEGENERATION JUNTENDO EDUCATIONAL FOUNDATION (JP) 2017-11-23 US claimed
WO-2001034199-A2 ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER ELI LILLY AND COMPANY (US) 2001-05-17 WO claimed
US-5563164-A TREATING ARTHRITIS, PSORIASIS, ASTHMA, INFLAMMATORY BOWEL DISEASE, OR ALZHEIMER'S DISEASE ELI LILLY AND COMPANY (US) 1996-10-08 US claimed
US-5478857-A Administering inhibitor of phospholipase A2 ELI LILLY AND COMPANY (US) 1995-12-26 US claimed
US-5294613-A Benzene derivatives of p-substituted ether and acid or ester ELI LILLY AND COMPANY (US) 1994-03-15 US claimed
US-4945099-A LEUKOTRIENE ANTAGONIST ELI LILLY AND COMPANY (US) 1990-07-31 US claimed
EP-0276065-B1 ANTI-INFLAMMATORY AGENTS ELI LILLY AND COMPANY (US) 1990-06-06 EP claimed
EP-0276065-A1 Anti-inflammatory agents ELI LILLY AND COMPANY (US) 1988-07-27 EP claimed
EP-4731002-A2 SYSTEMS FOR PRODUCTION OF PRODUCTS TO PROMOTE NITROGEN USE EFFICIENCY IN PLANTS Tenfold Technologies, LLC (US) 2026-04-29 EP disclosed
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 EP disclosed
WO-2024263793-A2 SYSTEMS FOR PRODUCTION OF PRODUCTS TO PROMOTE NITROGEN USE EFFICIENCY IN PLANTS Tenfold Technologies, LLC (US) 2024-12-26 WO disclosed
WO-2024168301-A2 PERSONALIZED CRISPR PROFILING FOR CANCER FUNCTION ONCOLOGY, INC. (US) 2024-08-15 WO disclosed
EP-3327001-B1 NOVEL COMPOUND HAVING BLT INHIBITORY ACTIVITY AND COMPOSITION, FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, COMPRISING SAME AS ACTIVE INGREDIENT UNIV DONGGUK IND ACAD COOP (KR) 2022-04-13 EP disclosed
WO-1995017183-A1 USE OF PLA2 INHIBITORS AS TREATMENT FOR ALZHEIMER'S DISEASE ELI LILLY AND COMPANY (US) 1995-06-29 WO disclosed
US-5294613-A Benzene derivatives of p-substituted ether and acid or ester ELI LILLY AND COMPANY (US) 1994-03-15 US disclosed
US-5098613-A Aromatic ethers for treatment of mammals ELI LILLY AND COMPANY (US) 1992-03-24 US disclosed
US-4945099-A LEUKOTRIENE ANTAGONIST ELI LILLY AND COMPANY (US) 1990-07-31 US disclosed
EP-0276065-A1 Anti-inflammatory agents ELI LILLY AND COMPANY (US) 1988-07-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170333516-A1 PREVENTIVE OR THERAPEUTIC AGENT FOR AGE-RELATED MACULAR DEGENERATION LTB4R, LTA4H, LTB4R2 NR1H4 1713/4885LTB4R 1/4885LTB4R2 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.