Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.50 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.46 |
| ▸ | CDC7 | O00311 | 4/20 | 0.44 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562597 | 0.82 | TGFBR1 (0.48) | TGFBR1IKBKETBK1PDPK1CDC7 | |
| SCHEMBL4562746 | 0.82 | DYRK1A (0.41) | TGFBR1IKBKETBK1PDPK1CDC7 | |
| SCHEMBL4562749 | 0.81 | CAMKK2 (0.46) | TGFBR1IKBKEPDPK1CDC7PIM1 | |
| SCHEMBL4562693 | 0.80 | GSK3B (0.38) | PDPK1PIM1GSK3BCDK2CDK9 | |
| SCHEMBL4556994 | 0.79 | PTPRC (0.47) | PIM1PRKACACDK2KMT2A | |
| SCHEMBL5618155 | 0.75 | TGFBR1 (0.71) | TGFBR1IKBKETBK1PDPK1CDC7 | |
| SCHEMBL4562747 | 0.72 | DYRK1A (0.41) | TGFBR1IKBKETBK1PDPK1CDC7 | |
| SCHEMBL4562750 | 0.71 | CAMKK2 (0.46) | TGFBR1IKBKEPDPK1CDC7PIM1 | |
| SCHEMBL31006144 | 0.70 | TGFBR1 (0.55) | TGFBR1IKBKETBK1PDPK1CDC7 | |
| SCHEMBL15397129 | 0.70 | IKBKE (0.78) | TGFBR1IKBKETBK1PDPK1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298820-A1 | 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298820-A1 | 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | MTOR, PIK3CA, PIK3C2B | TGFBR1 2437/4885IKBKE 400/4885TBK1 350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.