Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 11/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 11/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.40 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14144749 | 0.91 | HCRTR1 (0.45) | SCD5HCRTR1HCRTR2ROCK2 | |
| SCHEMBL342123 | 0.87 | ALDH1A1 (0.45) | DAGLAALDH1A1 | |
| SCHEMBL343089 | 0.87 | HCRTR1 (0.42) | HCRTR1HCRTR2ALDH1A2ALDH1A1ALDH1A3 | |
| SCHEMBL342144 | 0.85 | ALDH1A3 (0.50) | SCD5TRPV1HCRTR1HCRTR2ALDH1A2 | |
| SCHEMBL342337 | 0.85 | ALDH1A3 (0.40) | TRPV1HCRTR1HCRTR2ALDH1A2ALDH1A1 | |
| SCHEMBL342552 | 0.84 | PREP (0.43) | TRPV1HCRTR1HCRTR2ALDH1A2ALDH1A1 | |
| SCHEMBL14144748 | 0.78 | HCRTR1 (0.46) | HCRTR1HCRTR2ALDH1A2ALDH1A1ALDH1A3 | |
| SCHEMBL10184773 | 0.78 | XIAP (0.41) | — | |
| SCHEMBL14144746 | 0.76 | ALDH1A3 (0.47) | SCD5HCRTR1HCRTR2ALDH1A2ALDH1A1 | |
| SCHEMBL14144716 | 0.76 | GRM5 (0.40) | HCRTR1HCRTR2ALDH1A3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125809-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | Genentech, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079735-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-07-03 | — | — | WO | disclosed |