Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 5/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.36 |
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PPID | Q08752 | 1/20 | 0.34 |
| ▸ | PPIG | Q13427 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14144735 | 0.91 | PREP (0.41) | PREPUTS2RHTR2CHTR2AHCRTR1 | |
| SCHEMBL342144 | 0.87 | ALDH1A3 (0.50) | ALDH1A3ALDH1A2TRPV1PDE10AALDH1A1 | |
| SCHEMBL343089 | 0.86 | HCRTR1 (0.42) | ALDH1A3ALDH1A2PDE10AALDH1A1HCRTR1 | |
| SCHEMBL342337 | 0.86 | ALDH1A3 (0.40) | ALDH1A3ALDH1A2TRPV1PDE10AALDH1A1 | |
| SCHEMBL342833 | 0.86 | AADAT (0.42) | PREP | |
| SCHEMBL4563122 | 0.84 | SCD5 (0.42) | ALDH1A3ALDH1A2TRPV1ALDH1A1HCRTR1 | |
| SCHEMBL14144746 | 0.78 | ALDH1A3 (0.47) | ALDH1A3ALDH1A2ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL14144716 | 0.78 | GRM5 (0.40) | ALDH1A3HCRTR1HCRTR2 | |
| SCHEMBL14144748 | 0.78 | HCRTR1 (0.46) | ALDH1A3ALDH1A2ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL10182847 | 0.77 | XIAP (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-8063218-B2 | Imidazopyridine inhibitors of IAP | GENENTECH, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100130539-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH INC. (US) | 2010-05-27 | — | — | US | disclosed |
| EP-2125809-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | Genentech, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079735-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | PREP 523/4885UTS2R 1381/4885HTR2C 4621/4885 |
| US-20100130539-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | PREP 523/4885UTS2R 1381/4885HTR2C 4621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.