Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | MAT2A | P31153 | 2/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4563145 | 0.81 | DHFR (0.44) | NOTUMXDH | |
| SCHEMBL4562527 | 0.79 | ALDH1A1 (0.45) | GAACYP1A2NOTUMXDHMEN1 | |
| SCHEMBL4562987 | 0.78 | ALDH1A1 (0.46) | ALOX5NOTUMXDHMAT2A | |
| SCHEMBL17537376 | 0.74 | CYP1A2 (0.58) | GAACYP1A2HTTBRD9ALOX5 | |
| SCHEMBL11551929 | 0.74 | HTT (0.56) | GAACYP1A2HTTBRD9NOTUM | |
| SCHEMBL5871981 | 0.74 | GAA (0.50) | GAACYP1A2HTTBRD9ALOX5 | |
| SCHEMBL28744564 | 0.74 | GAA (0.63) | GAACYP1A2HTTBRD9ALOX5 | |
| SCHEMBL5534269 | 0.73 | CYP1A2 (0.54) | GAACYP1A2HTTBRD9ALOX5 | |
| SCHEMBL4563247 | 0.73 | HPN (0.49) | CYP1A2MEN1KMT2A | |
| SCHEMBL403594 | 0.73 | POLB (0.56) | GAACYP1A2HTTALOX5PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318491-A1 | Cytisine and Acetylcholine Analogs and Methods of Treating Mood Disorders | YALE UNIVERISTY (US) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318491-A1 | Cytisine and Acetylcholine Analogs and Methods of Treating Mood Disorders | CHRNA1, CHRNA5, CHRNA10 | GAA 3032/4885CYP1A2 1000/4885HTT 1610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.