Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562527 | 0.78 | ALDH1A1 (0.45) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4563051 | 0.77 | FAAH (0.44) | MAPK14NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL543835 | 0.75 | MAPT (0.56) | HPNSCN2AMAPK14NPC1RAB9A | |
| SCHEMBL5328812 | 0.71 | HPN (0.58) | HPNSCN2ANPC1RAB9AALDH1A1 | |
| SCHEMBL2627226 | 0.69 | SCN2A (0.57) | HPNSCN2ANPC1RAB9AALDH1A1 | |
| SCHEMBL30782027 | 0.69 | SCN2A (0.57) | HPNSCN2ANPC1RAB9AALDH1A1 | |
| SCHEMBL17172464 | 0.69 | MAPT (0.57) | HPNSCN2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL28287781 | 0.69 | ALDH1A1 (0.64) | HPNSCN2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL345273 | 0.68 | ALDH1A1 (0.48) | ALDH1A1MAPTCYP3A4MEN1KMT2A | |
| SCHEMBL3311690 | 0.68 | ALDH1A1 (0.48) | ALDH1A1MAPTCYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318491-A1 | Cytisine and Acetylcholine Analogs and Methods of Treating Mood Disorders | YALE UNIVERISTY (US) | 2009-12-24 | — | — | US | disclosed |
| EP-1976519-A2 | CYTISINE AND ACETYLCHOLINE ANALOGS AND METHODS OF TREATING MOOD DISORDERS | Yale University (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007100430-A2 | CYTISINE AND ACETYLCHOLINE ANALOGS AND METHODS OF TREATING MOOD DISORDERS | YALE UNIVERSITY (US) | 2007-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318491-A1 | Cytisine and Acetylcholine Analogs and Methods of Treating Mood Disorders | CHRNA1, CHRNA5, CHRNA10 | HPN 4343/4885SCN2A 1356/4885MAPK14 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.