Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 12/20 | 0.42 |
| ▸ | MEN1 | O00255 | 11/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.39 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | UBE2I | P63279 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1554635 | 0.87 | MEN1 (0.48) | KMT2AMEN1NPC1SCN2AALDH1A1 | |
| SCHEMBL4259340 | 0.87 | NR1H4 (0.39) | KMT2AMEN1NPC1ALDH1A1RAB9A | |
| SCHEMBL1554791 | 0.87 | ALDH1A1 (0.46) | KMT2AMEN1NPC1SCN2AALDH1A1 | |
| SCHEMBL1553399 | 0.86 | KMT2A (0.38) | KMT2AMEN1NPC1SCN2AALDH1A1 | |
| SCHEMBL4256946 | 0.86 | ALDH1A1 (0.56) | KMT2AMEN1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1553831 | 0.84 | MEN1 (0.46) | KMT2AMEN1NPC1SCN2AALDH1A1 | |
| SCHEMBL1553923 | 0.84 | AR (0.49) | KMT2AMEN1NPC1ALDH1A1RAB9A | |
| SCHEMBL1553601 | 0.83 | ALDH1A1 (0.42) | KMT2AMEN1NPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3972241 | 0.82 | MEN1 (0.46) | KMT2AMEN1NPC1SCN2AALDH1A1 | |
| SCHEMBL1553944 | 0.81 | POLB (0.44) | KMT2AMEN1NPC1SCN2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383463-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | KING PHARMACEUTICALS INC (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1383463-A2 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | King Pharmaceuticals, Inc. (US) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002083083-A2 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | KING PHARMACEUTICALS, INC. (US) | 2002-10-24 | — | — | WO | disclosed |