Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1539124 | 0.87 | KMT2A (0.52) | KMT2AALDH1A1MAPTTDP1KDM4E | |
| SCHEMBL2568138 | 0.81 | KDM4E (0.65) | KMT2AALDH1A1MAPTTDP1KDM4E | |
| SCHEMBL19848314 | 0.80 | ALDH1A1 (0.47) | KMT2AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL1539099 | 0.77 | FGFR1 (0.46) | KMT2AALDH1A1MAPTLMNAHTT | |
| SCHEMBL10893089 | 0.77 | NPC1 (0.46) | KMT2AALDH1A1MAPTTDP1KDM4E | |
| SCHEMBL6536735 | 0.77 | PRPS1 (0.42) | KMT2AALDH1A1MAPTTDP1KDM4E | |
| SCHEMBL623907 | 0.77 | MAPT (0.64) | KMT2AALDH1A1MAPTTDP1KDM4E | |
| SCHEMBL10891799 | 0.77 | MAPT (0.41) | KMT2AALDH1A1MAPTTDP1KDM4E | |
| SCHEMBL9678684 | 0.77 | ALDH1A1 (0.43) | KMT2AALDH1A1KDM4ELMNAHTT | |
| SCHEMBL7643046 | 0.77 | FGFR1 (0.50) | ALDH1A1MAPTTDP1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061464-A2 | COMBINATION THERAPY FOR TUMORAL DISEASE TREATMENT | Ramot, at Tel Aviv University Ltd. (IL) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008032324-A2 | COMBINATION THERAPY FOR TUMORAL DISEASE TREATMENT | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2008-03-20 | — | — | WO | disclosed |