Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL416541 | 0.77 | ELANE (0.53) | FAAHSMN1; SMN2MAPTSMYD3HRH4 | |
| SCHEMBL456348 | 0.74 | SMYD3 (0.47) | FAAHSMN1; SMN2SMYD3HRH4CNR2 | |
| SCHEMBL11795043 | 0.74 | MAPT (0.68) | FAAHSMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL30786706 | 0.73 | FAAH (0.60) | FAAHSMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL30786707 | 0.73 | FAAH (0.60) | FAAHSMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL29183540 | 0.73 | FAAH (0.60) | FAAHSMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL27573147 | 0.70 | SMN1; SMN2 (0.58) | FAAHSMN1; SMN2ALDH1A1HRH4CNR2 | |
| SCHEMBL1757287 | 0.69 | AURKA (0.59) | FAAHSMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL18866434 | 0.69 | MAPT (0.66) | FAAHSMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL7469771 | 0.69 | SMN1; SMN2 (0.49) | FAAHSMN1; SMN2KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613630-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | Cempra Pharmaceuticals, Inc. (US) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012034058-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | CEMPRA PHARMACEUTICALS, INC. (US) | 2012-03-15 | — | — | WO | disclosed |