Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.47 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL416541 | 0.77 | ELANE (0.53) | SMYD3SMN1; SMN2NPC1RAB9AFAAH | |
| SCHEMBL454902 | 0.75 | MAOB (0.64) | FAAHHRH4 | |
| SCHEMBL456347 | 0.74 | FAAH (0.47) | SMYD3SMN1; SMN2NPC1RAB9AFAAH | |
| SCHEMBL6670417 | 0.74 | IDO1 (0.55) | NPC1RAB9AHRH4POLB | |
| SCHEMBL1255702 | 0.74 | IDO1 (0.55) | NPC1RAB9AHRH4POLB | |
| SCHEMBL11343167 | 0.73 | KHK (0.52) | SMN1; SMN2TDP1POLB | |
| SCHEMBL1901781 | 0.71 | SMN1; SMN2 (0.61) | DAGLASMN1; SMN2NPC1RAB9AHRH4 | |
| SCHEMBL29414979 | 0.71 | XDH (0.62) | SMYD3DAGLASMN1; SMN2NPC1RAB9A | |
| SCHEMBL30831206 | 0.71 | SMN1; SMN2 (0.61) | DAGLASMN1; SMN2NPC1RAB9AHRH4 | |
| SCHEMBL6039391 | 0.71 | DAGLA (0.57) | DAGLASMN1; SMN2NPC1RAB9AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613630-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | Cempra Pharmaceuticals, Inc. (US) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012034058-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | CEMPRA PHARMACEUTICALS, INC. (US) | 2012-03-15 | — | — | WO | disclosed |