Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CTRC | Q99895 | 2/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703851 | 0.83 | GSTP1 (0.49) | SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL6068229 | 0.82 | AHR (0.39) | CYP2A6CYP1A2ALOX5KDM4ELMNA | |
| SCHEMBL15287170 | 0.79 | TDO2 (0.41) | ALOX5SMN1; SMN2MEN1KMT2AESR2 | |
| SCHEMBL457904 | 0.78 | CYP2A6 (0.41) | CYP2A6CTRCCSNK2A1CYP1A2BACE1 | |
| SCHEMBL7814278 | 0.78 | CYP2A6 (0.41) | CYP2A6CTRCCSNK2A1CYP1A2BACE1 | |
| SCHEMBL6206554 | 0.78 | CYP2A6 (0.41) | CYP2A6CTRCCSNK2A1CYP1A2BACE1 | |
| SCHEMBL454901 | 0.78 | ALDH1A1 (0.41) | CYP2A6CTRCCSNK2A1CYP1A2BACE1 | |
| SCHEMBL455577 | 0.78 | ALDH1A1 (0.41) | CYP2A6CTRCCSNK2A1CYP1A2BACE1 | |
| SCHEMBL7814348 | 0.78 | CYP2A6 (0.41) | CYP2A6CTRCCSNK2A1CYP1A2BACE1 | |
| SCHEMBL12503755 | 0.78 | CYP2A6 (0.41) | CYP2A6CTRCCSNK2A1CYP1A2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423119-A4 | HETEROBICYCLES FKBP-LIGANDS | AGOURON PHARMA (US) | 2005-04-13 | — | — | EP | claimed |
| EP-1423119-A1 | HETEROBICYCLES FKBP-LIGANDS | Agouron Pharmaceuticals, Inc. (US) | 2004-06-02 | — | — | EP | claimed |
| WO-2002089806-A1 | HETEROBICYCLES FKBP-LIGANDS | AGOURON PHARMACEUTICALS, INC. (US) | 2002-11-14 | — | — | WO | claimed |
| US-9307767-B2 | Herbicidally and insecticidally active thiazolopyridinones | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-04-12 | — | — | US | disclosed |
| EP-2831084-B1 | HERBICIDAL AND INSECTICIDAL THIAZOLOPYRIDINONES | BAYER IP GMBH (DE) | 2016-03-23 | — | — | EP | disclosed |
| US-20150045217-A1 | Herbicidally and Insecticidally Active Thiazolopyridinones | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2015-02-12 | — | — | US | disclosed |
| EP-2831084-A1 | HERBICIDALLY AND INSECTICIDALLY ACTIVE THIAZOLOPYRIDINONES | Bayer Intellectual Property GmbH (DE) | 2015-02-04 | — | — | EP | disclosed |
| WO-2013144096-A1 | HERBICIDALLY AND INSECTICIDALLY ACTIVE THIAZOLOPYRIDINONES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-10-03 | — | — | WO | disclosed |
| EP-2614053-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012033225-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-03-15 | — | — | WO | disclosed |
| US-4952580-A | NEMATOCIDES, ANTHELMINTICS | FMC CORPORATION (US) | 1990-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045217-A1 | Herbicidally and Insecticidally Active Thiazolopyridinones | CBR3, DDT, CBR1 | CYP2A6 486/4885CTRC 565/4885CSNK2A1 3051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.