Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 5/20 | 0.53 |
| ▸ | NOS1 | P29475 | 5/20 | 0.53 |
| ▸ | NOS2 | P35228 | 5/20 | 0.53 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | USP8 | P40818 | 1/20 | 0.35 |
| ▸ | OTUB1 | Q96FW1 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL954571 | 0.90 | NOS3 (0.64) | NOS3NOS1NOS2SOS1USP2 | |
| SCHEMBL221052 | 0.90 | NOS3 (0.64) | NOS3NOS1NOS2SOS1USP2 | |
| SCHEMBL4563534 | 0.89 | NOS3 (0.40) | NOS3NOS1NOS2SOS1USP2 | |
| SCHEMBL220425 | 0.85 | NOS3 (0.56) | NOS3NOS1NOS2SOS1CDK2 | |
| SCHEMBL222403 | 0.84 | NOS3 (0.54) | NOS3NOS1NOS2SOS1USP2 | |
| SCHEMBL422148 | 0.78 | NOS3 (0.47) | NOS3NOS1NOS2SOS1USP2 | |
| SCHEMBL221344 | 0.76 | NOS1 (0.65) | NOS3NOS1NOS2PDE3BPDE3A | |
| SCHEMBL6584972 | 0.76 | NOS3 (0.62) | NOS3NOS1NOS2USP2USP1 | |
| SCHEMBL956395 | 0.74 | NOS3 (0.60) | NOS3NOS1NOS2USP2USP1 | |
| SCHEMBL221743 | 0.73 | PRKCZ (0.45) | NOS3NOS1NOS2SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158646-A1 | THERAPEUTIC COMPUNDS AND RELATED METHODS OF USE | ELIXIR PHARMACEUTICALS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2006094210-A2 | TETRAHYDROQUINOXALINONE SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2006-09-08 | — | — | WO | disclosed |