Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | NPY2R | P49146 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4426402 | 0.90 | CACNA2D1 (0.51) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL3859892 | 0.83 | CACNA1B (0.46) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL4419615 | 0.83 | OPRD1 (0.39) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL4413372 | 0.77 | CACNA2D1 (0.37) | CACNA2D1CACNA1BCACNB1CACNA1CHTR2B | |
| SCHEMBL5023769 | 0.75 | KDM4E (0.43) | MEN1KMT2A | |
| SCHEMBL8211709 | 0.75 | CACNA2D1 (0.53) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL2791861 | 0.74 | CACNA2D1 (0.57) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL2794375 | 0.73 | CACNA2D1 (0.73) | CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL2796769 | 0.72 | CACNA2D1 (0.53) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL2794772 | 0.71 | CACNA2D1 (0.52) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061780-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008031227-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2008-03-20 | — | — | WO | disclosed |