Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4563537 | 0.75 | CACNA2D1 (0.43) | MEN1KMT2A | |
| SCHEMBL4426402 | 0.73 | CACNA2D1 (0.51) | CYP2D6CHRM3 | |
| SCHEMBL5271920 | 0.72 | CACNA2D1 (0.55) | MEN1KMT2ACYP2D6CYP3A4CYP2C19 | |
| SCHEMBL4182736 | 0.72 | CACNA2D1 (0.58) | KMT2ACYP2D6ALDH1A1 | |
| SCHEMBL3859892 | 0.71 | CACNA1B (0.46) | KDM4EMEN1KMT2ACYP2D6CYP3A4 | |
| SCHEMBL5024049 | 0.70 | ALDH1A1 (0.45) | KDM4EKMT2ATSHRALDH1A1 | |
| SCHEMBL4419615 | 0.69 | OPRD1 (0.39) | — | |
| SCHEMBL5023619 | 0.68 | DRD2 (0.51) | — | |
| SCHEMBL26192614 | 0.66 | OPRM1 (0.61) | KDM4EMEN1KMT2ACYP2D6CYP2C19 | |
| SCHEMBL10269322 | 0.66 | CHRNA7 (0.56) | KDM4ERAD52ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871372-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | Neuromed Pharmaceuticals, Ltd. (CA) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006105670-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | NEUROMED PHARMACEUTICALS LTD. (CA) | 2006-10-12 | — | — | WO | disclosed |