Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.50 |
| ▸ | JAK3 | P52333 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | GMNN | O75496 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3336117 | 0.85 | GPR119 (0.54) | JAK2JAK3 | |
| SCHEMBL8408533 | 0.79 | DRD2 (0.64) | JAK2JAK3ALDH1A1TDP1GMNN | |
| SCHEMBL3335575 | 0.78 | HRH2 (0.41) | JAK2JAK3ALDH1A1TDP1GMNN | |
| SCHEMBL8169539 | 0.77 | JAK2 (0.50) | JAK2JAK3JAK1 | |
| SCHEMBL4118965 | 0.75 | JAK2 (0.46) | JAK2JAK3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8169931 | 0.74 | JAK2 (0.41) | JAK2JAK3ALDH1A1TDP1GMNN | |
| SCHEMBL27226227 | 0.74 | GPR119 (0.43) | JAK2JAK3JAK1TYK2KCNH2 | |
| SCHEMBL13302528 | 0.71 | JAK2 (0.47) | JAK2JAK3KCNH2 | |
| SCHEMBL13003301 | 0.70 | CHRM3 (0.55) | ALDH1A1TDP1GMNNLMNADRD2 | |
| SCHEMBL2896994 | 0.70 | L3MBTL3 (0.46) | DRD2DRD4DRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134687-A1 | PIPERAZINE AND PIPERIDINE MGLUR5 POTENTIATORS | AstraZeneca AB (SE) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008112440-A1 | PIPERAZINE AND PIPERIDINE MGLUR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2008-09-18 | — | — | WO | disclosed |