Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 13/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14145065 | 0.91 | HCRTR1 (0.45) | DRD2DRD4DRD3HCRTR1HCRTR2 | |
| SCHEMBL341458 | 0.86 | GFER (0.47) | — | |
| SCHEMBL342144 | 0.84 | ALDH1A3 (0.50) | HCRTR1HCRTR2TRPV1SCD5SCD | |
| SCHEMBL342015 | 0.79 | TRPV1 (0.38) | HCRTR1HCRTR2TRPV1SCD5SCD | |
| SCHEMBL343089 | 0.79 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL10182858 | 0.78 | XIAP (0.43) | — | |
| SCHEMBL14145066 | 0.77 | HCRTR1 (0.40) | DRD2DRD4DRD3HCRTR1HCRTR2 | |
| SCHEMBL342337 | 0.74 | ALDH1A3 (0.40) | HCRTR1HCRTR2TRPV1 | |
| SCHEMBL14144746 | 0.74 | ALDH1A3 (0.47) | HCRTR1HCRTR2SCD5SCDGRM5 | |
| SCHEMBL4563122 | 0.74 | SCD5 (0.42) | HCRTR1HCRTR2TRPV1SCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125809-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | Genentech, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079735-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-07-03 | — | — | WO | disclosed |