Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 3/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4563907 | 0.74 | MEN1 (0.46) | TACR1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1895537 | 0.74 | ABCB1 (0.50) | TACR1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28815916 | 0.71 | BCAT2 (0.54) | TACR1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2484726 | 0.70 | MEN1 (0.61) | TACR1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1826396 | 0.68 | CHRNB2 (0.65) | ALDH1A1MEN1KMT2ASMN1; SMN2BCAT2 | |
| SCHEMBL30345390 | 0.68 | CHRNB2 (0.65) | ALDH1A1MEN1KMT2ASMN1; SMN2BCAT2 | |
| SCHEMBL3629780 | 0.67 | MEN1 (0.66) | TACR1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Biphenyl SCHEMBL27596494 | 0.67 | CHRNB2 (0.62) | ALDH1A1MEN1KMT2ASMN1; SMN2BCAT2 | |
| SCHEMBL8696618 | 0.66 | KMT2A (0.71) | TACR1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14134492 | 0.66 | MEN1 (0.58) | TACR1ALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124921-A2 | SULFONYL SEMICARBAZIDES, CARBONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES | SIGA TECHNOLOGIES, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008147474-A2 | SULFONYL SEMICARBAZIDES, CARBONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES | SIGA TECHNOLOGIES, INC. (US) | 2008-12-04 | — | — | WO | disclosed |