Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TACR1 | P25103 | 2/20 | 0.54 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | FABP3 | P05413 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28815916 | 0.80 | BCAT2 (0.54) | MEN1KMT2ASMN1; SMN2TACR1BCAT2 | |
| SCHEMBL202347 | 0.77 | MEN1 (0.54) | MEN1KMT2ASMN1; SMN2TACR1BCAT2 | |
| SCHEMBL30463435 | 0.76 | MEN1 (1.00) | MEN1KMT2ASMN1; SMN2TACR1BCAT2 | |
| SCHEMBL12984615 | 0.76 | KMT2A (0.49) | MEN1KMT2ASMN1; SMN2TACR1BCAT2 | |
| SCHEMBL307520 | 0.76 | BCAT2 (0.57) | MEN1KMT2ASMN1; SMN2TACR1BCAT2 | |
| SCHEMBL6677412 | 0.76 | MEN1 (1.00) | MEN1KMT2ASMN1; SMN2TACR1BCAT2 | |
| SCHEMBL3629780 | 0.75 | MEN1 (0.66) | MEN1KMT2ASMN1; SMN2TACR1BCAT2 | |
| Trifluoroacetic Acid SCHEMBL16720000 | 0.74 | HNF4A (0.56) | MEN1KMT2ASMN1; SMN2TACR1BCAT2 | |
| Hydrochloric Acid SCHEMBL20578422 | 0.74 | MEN1 (0.96) | MEN1KMT2ASMN1; SMN2TACR1BCAT2 | |
| SCHEMBL29035974 | 0.74 | BCAT2 (0.55) | MEN1KMT2ASMN1; SMN2TACR1BCAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2375904-A1 | BIARYL CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2011-10-19 | — | — | EP | claimed |
| WO-2010077624-A1 | BIARYL CARBOXAMIDES | MERCK SHARP & DOHME CORP. (US) | 2010-07-08 | — | — | WO | claimed |