Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.30 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
| ▸ | HTR2B | P41595 | 2/20 | 0.30 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555969 | 0.87 | TP53 (0.33) | — | |
| SCHEMBL4864529 | 0.84 | GPER1 (0.35) | — | |
| SCHEMBL4884506 | 0.83 | ALDH1A1 (0.33) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL4863542 | 0.82 | ALDH1A1 (0.33) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL4762777 | 0.81 | — | — | |
| SCHEMBL4556127 | 0.79 | GHSR (0.32) | — | |
| SCHEMBL4570046 | 0.72 | HCRTR1 (0.32) | HTR1A | |
| SCHEMBL4556008 | 0.71 | PSMB5 (0.39) | — | |
| SCHEMBL4569657 | 0.71 | PGR (0.33) | — | |
| SCHEMBL4442827 | 0.71 | CACNA1C (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125825-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079139-A1 | ABCA1 ELEVATING COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |