Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 5/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | LIG1 | P18858 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4339855 | 0.69 | KDM1A (0.53) | KDM1ARCOR1MAPK1LIG1MEN1 | |
| SCHEMBL12013615 | 0.66 | LMNA (0.46) | KDM1ARCOR1MAPK1CHRNA7MEN1 | |
| SCHEMBL10699001 | 0.64 | SLC6A2 (0.44) | SLC6A2SLC6A3CHRNA7TAAR1 | |
| SCHEMBL25381591 | 0.64 | SLC6A2 (0.44) | SLC6A2SLC6A3CHRNA7TAAR1 | |
| SCHEMBL30052241 | 0.62 | KDM1A (0.42) | KDM1ARCOR1MAPK1LIG1CHRNA7 | |
| SCHEMBL10750020 | 0.62 | LIG1 (0.46) | KDM1ARCOR1MAPK1LIG1SLC6A2 | |
| Bicarbonate SCHEMBL10971534 | 0.62 | MAPK1 (0.50) | KDM1ARCOR1MAPK1LIG1MEN1 | |
| SCHEMBL9515156 | 0.61 | KDM1A (0.49) | KDM1ARCOR1MAPK1LIG1MEN1 | |
| SCHEMBL9515155 | 0.61 | KDM1A (0.49) | KDM1ARCOR1MAPK1LIG1MEN1 | |
| SCHEMBL10292141 | 0.60 | HTR3A (0.49) | KDM1ARCOR1LIG1SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109615-A1 | SUBSTITUTED PYRANO [2, 3 - B]PYRIDINE DERIVATIVES AS CANNABINOID-1 RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2009-10-21 | — | — | EP | disclosed |
| WO-2008094476-A1 | SUBSTITUTED PYRANO [2, 3 - B] PYRIDINE DERIVATIVES AS CANNABINOID -1 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-08-07 | — | — | WO | disclosed |