Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13593620 | 0.65 | P2RX7 (0.47) | ARSIGMAR1CACNA1FDRD1DRD4 | |
| SCHEMBL3796885 | 0.64 | GFER (0.67) | HTR7ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL4564244 | 0.63 | CHRM5 (0.34) | CHRM5CHRM1CHRM3MEN1KMT2A | |
| SCHEMBL13182943 | 0.62 | ALDH1A1 (0.48) | ARSIGMAR1CHRM5CHRM3CACNA1F | |
| SCHEMBL6954266 | 0.62 | CYP1A2 (0.57) | ADRA1ASLC6A3ALDH1A1 | |
| SCHEMBL6400131 | 0.62 | CYP1A2 (0.41) | — | |
| SCHEMBL13593621 | 0.61 | DPP4 (0.66) | PTGDR2 | |
| SCHEMBL12835353 | 0.61 | DPP4 (0.46) | PTGDR2 | |
| SCHEMBL7730871 | 0.61 | NPC1 (0.68) | ARSIGMAR1CACNA1FDRD1DRD4 | |
| SCHEMBL24533902 | 0.61 | POLB (0.56) | ARSIGMAR1CHRM1CACNA1FDRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1808168-B1 | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level | ARENA PHARM INC (US) | 2009-06-03 | — | — | EP | disclosed |