Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.38 |
| ▸ | IL6 | P05231 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15640908 | 0.74 | LMNA (0.48) | RAF1BRAFNPC1RAB9ATP53 | |
| SCHEMBL3021481 | 0.73 | RAF1 (0.67) | RAF1BRAFNPC1RAB9ATP53 | |
| SCHEMBL1467043 | 0.73 | RAF1 (0.86) | RAF1BRAFNPC1RAB9ATP53 | |
| SCHEMBL4564390 | 0.71 | RAF1 (0.61) | RAF1BRAFNPC1RAB9ATP53 | |
| SCHEMBL14097676 | 0.70 | SMN1; SMN2 (0.58) | RAF1BRAFNPC1RAB9ATP53 | |
| SCHEMBL31430624 | 0.62 | LCK (0.57) | NPC1RAB9ATP53SMN1; SMN2HDAC6 | |
| SCHEMBL31430564 | 0.59 | LCK (0.56) | NPC1RAB9ATP53SMN1; SMN2HDAC6 | |
| SCHEMBL24894178 | 0.59 | NPC1 (0.61) | RAF1BRAFNPC1RAB9ATP53 | |
| SCHEMBL30194619 | 0.59 | NPC1 (0.61) | RAF1BRAFNPC1RAB9ATP53 | |
| SCHEMBL5369888 | 0.59 | THRB (0.57) | HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |
| US-8697737-B2 | Raf modulators and methods of use | EXELIXIS, INC. (US) | 2014-04-15 | — | — | US | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |