SCHEMBL4564463

SCHEMBL4564463

Cc1cc(COc2ccc(C(=O)NC[C@H]3CN(C(=O)OC(C)(C)C)C[C@]34NC(=O)NC4=O)cc2)c2ccccc2n1

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MMP12 P39900 2/20 0.69
ADAM17 P78536 3/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4055856 1.00 MMP12 (0.69) MMP12ADAM17
SCHEMBL4055859 1.00 MMP12 (0.69) MMP12ADAM17
SCHEMBL4057886 0.90 ADAM17 (0.58) MMP12ADAM17
SCHEMBL4057881 0.90 ADAM17 (0.58) MMP12ADAM17
SCHEMBL4444707 0.83 MMP12 (0.66) MMP12ADAM17
SCHEMBL4057393 0.83 MMP12 (0.66) MMP12ADAM17
SCHEMBL4048253 0.82 MMP2 (0.70) ADAM17
SCHEMBL4051048 0.82 ADAM17 (0.66) MMP12ADAM17
SCHEMBL4048249 0.82 MMP2 (0.70) ADAM17
SCHEMBL4051053 0.82 ADAM17 (0.66) MMP12ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1397137-B1 HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES BRISTOL MYERS SQUIBB CO (US) 2009-10-14 EP claimed