Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236145 | 0.86 | L3MBTL1 (0.41) | ALDH1A1L3MBTL1TSHRGLAPARP10 | |
| SCHEMBL2065189 | 0.82 | LMNA (0.43) | ALDH1A1L3MBTL1TSHRGLANPC1 | |
| SCHEMBL27466888 | 0.80 | L3MBTL1 (0.42) | ALDH1A1L3MBTL1TSHRGLANPC1 | |
| SCHEMBL11310669 | 0.76 | ALDH1A1 (0.50) | ALDH1A1PARP10NPC1RAB9ALMNA | |
| SCHEMBL11290932 | 0.76 | SMN1; SMN2 (0.39) | L3MBTL1PARP10ALOX15SMN1; SMN2CYP1A2 | |
| SCHEMBL10477934 | 0.74 | PARP10 (0.41) | L3MBTL1TSHRPARP10ALOX15HSD17B10 | |
| Formaldehyde SCHEMBL27540839 | 0.73 | TP53 (0.39) | PARP10LMNAMAPTNPSR1CTNNB1 | |
| SCHEMBL7538756 | 0.72 | NPC1 (0.54) | ALDH1A1L3MBTL1TSHRNPC1RAB9A | |
| SCHEMBL19693446 | 0.71 | TP53 (0.43) | TSHRNPC1RAB9ALMNAALOX15 | |
| SCHEMBL11312887 | 0.70 | ELANE (0.55) | ALDH1A1L3MBTL1NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |