Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250163 | 0.95 | TDP1 (0.39) | TDP1L3MBTL1PPARAPTGDR2TRPV1 | |
| SCHEMBL29951676 | 0.88 | CYP2E1 (0.44) | TDP1L3MBTL1PTGDR2CYP2E1CYP2C8 | |
| SCHEMBL31068616 | 0.82 | CYP2A6 (0.42) | CYP2E1CYP2C8CYP2D6CYP2A6CYP2C9 | |
| SCHEMBL14872350 | 0.82 | CYP2A6 (0.42) | CYP2E1CYP2C8CYP2D6CYP2A6CYP2C9 | |
| SCHEMBL5400615 | 0.78 | TDP1 (0.53) | TDP1L3MBTL1LIPGPPARAPTGDR2 | |
| SCHEMBL9820954 | 0.77 | TDP1 (0.49) | TDP1L3MBTL1LIPGPPARAPTGDR2 | |
| SCHEMBL10435113 | 0.77 | TDP1 (0.49) | TDP1L3MBTL1LIPGPPARAPTGDR2 | |
| SCHEMBL28328248 | 0.77 | TDP1 (0.49) | TDP1L3MBTL1LIPGPPARAPTGDR2 | |
| SCHEMBL23768500 | 0.77 | TDP1 (0.52) | TDP1L3MBTL1LIPGPPARAPTGDR2 | |
| SCHEMBL10598588 | 0.77 | TDP1 (0.52) | TDP1L3MBTL1LIPGPPARAPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528256-B2 | Process for the preparation of nicotinaldehydes | MERCK PATENT GMBH (DE) | 2009-05-05 | — | — | US | disclosed |
| US-20060199965-A1 | Process for the preparation of nicotinaldehydes | MERCK PATENT GMBH (DE) | 2006-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199965-A1 | Process for the preparation of nicotinaldehydes | NAMPT, NAPRT, NNMT | TDP1 3319/4885L3MBTL1 4878/4885HIF1A 3982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.