Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 4/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4564968 | 0.95 | TDP1 (0.45) | TDP1L3MBTL1CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL29951676 | 0.89 | CYP2E1 (0.44) | TDP1L3MBTL1CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL31068616 | 0.83 | CYP2A6 (0.42) | CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL14872350 | 0.83 | CYP2A6 (0.42) | CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL9587868 | 0.77 | TDP1 (0.46) | TDP1L3MBTL1CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL8765675 | 0.77 | TDP1 (0.42) | TDP1L3MBTL1KDM6BKDM4CNPC1 | |
| SCHEMBL8765014 | 0.77 | L3MBTL1 (0.42) | TDP1L3MBTL1CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL2098173 | 0.75 | TDP1 (0.41) | TDP1L3MBTL1CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL18995860 | 0.75 | CYP2D6 (0.45) | TDP1L3MBTL1CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL266417 | 0.74 | LIPG (0.47) | TDP1L3MBTL1CYP2D6CYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401275-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | Respiratorius AB (SE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097410-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | RESPIRATORIUS AB (SE) | 2010-09-02 | — | — | WO | disclosed |
| US-4904675-A | Phamacologically active 5-carboxy-2-(5-tetrazolyl) pyridines | ZYMA SA (CH) | 1990-02-27 | — | — | US | disclosed |
| EP-0278908-A2 | Heterocyclic compounds | Zyma SA (CH) | 1988-08-17 | — | — | EP | disclosed |