Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541481 | 0.96 | RAB9A (0.47) | RAB9ANPC1FASNNAMPTROCK2 | |
| SCHEMBL14473018 | 0.88 | RAB9A (0.50) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL4420730 | 0.87 | RAB9A (0.50) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL4409531 | 0.87 | RAF1 (0.42) | RAF1BRAF | |
| SCHEMBL5593020 | 0.86 | RAB9A (0.49) | RAB9ANPC1FASNNAMPTROCK2 | |
| SCHEMBL4412596 | 0.86 | ACKR3 (0.43) | RAB9ANPC1RAF1MAPK14MAPT | |
| SCHEMBL4412422 | 0.86 | RAB9A (0.51) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL4409551 | 0.86 | RAF1 (0.43) | RAF1BRAF | |
| SCHEMBL4541476 | 0.86 | RAB9A (0.49) | RAB9ANPC1FASNNAMPTROCK2 | |
| SCHEMBL4418487 | 0.85 | MAPK14 (0.48) | NAMPTRAF1HSPB1MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |