Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 4/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 3/20 | 0.39 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4410942 | 0.89 | BRAF (0.45) | RAF1BRAFCSF1R | |
| SCHEMBL5593352 | 0.88 | RAF1 (0.41) | MAPK14RAF1BRAFNPC1MAPT | |
| SCHEMBL4565287 | 0.86 | RAB9A (0.47) | MAPK14RAF1BRAFNPC1MAPT | |
| SCHEMBL4408593 | 0.86 | TEK (0.43) | ACKR3MAPK14KDM4ERAF1BRAF | |
| SCHEMBL4409531 | 0.86 | RAF1 (0.42) | RAF1BRAFCSF1R | |
| SCHEMBL4409551 | 0.85 | RAF1 (0.43) | RAF1BRAFCSF1R | |
| SCHEMBL5593311 | 0.85 | RAF1 (0.46) | RAF1BRAFCSF1R | |
| SCHEMBL4416214 | 0.82 | MAPK14 (0.43) | MAPK14RAF1BRAFNPC1MAPT | |
| SCHEMBL4415069 | 0.82 | MAPK14 (0.47) | MAPK14KDM4ERAF1BRAFNPC1 | |
| SCHEMBL4541481 | 0.82 | RAB9A (0.47) | MAPK14MAPK13RAF1BRAFNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |