Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 11/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692213 | 0.91 | PTGER4 (0.61) | PTGER4PTGER2ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL4014465 | 0.86 | TAS1R3 (0.51) | PTGER4PTGER2ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL692571 | 0.83 | PTGER4 (0.72) | PTGER4PTGER2ALDH1A1PTGDR | |
| SCHEMBL4017992 | 0.79 | PTGER4 (0.60) | PTGER4PTGER2ALDH1A1 | |
| SCHEMBL691859 | 0.78 | PTGER4 (0.60) | PTGER4PTGER2PTGER1PTGDR | |
| SCHEMBL5502156 | 0.77 | CA1 (0.50) | PTGER4PTGER2ALDH1A1PTGDRKCNH2 | |
| SCHEMBL691725 | 0.75 | PTGER4 (0.65) | PTGER4PTGER2ALDH1A1PTGDR | |
| SCHEMBL27667223 | 0.75 | PTGER4 (0.65) | PTGER4PTGER2ALDH1A1PTGDR | |
| SCHEMBL2492541 | 0.75 | PTGER4 (0.65) | PTGER4PTGER2PTGER1PTGDR | |
| SCHEMBL692039 | 0.75 | PTGER4 (0.65) | PTGER4PTGER2PTGER1PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005102389-A9 | COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2009-04-30 | — | — | WO | disclosed |