Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 5/20 | 0.51 |
| ▸ | NOS1 | P29475 | 4/20 | 0.47 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054430 | 0.87 | NOS2 (0.67) | NOS2NOS1NOS3ALDH1A1MEN1 | |
| Ammonia Solution, Strong SCHEMBL3061153 | 0.86 | NOS2 (0.66) | NOS2NOS1NOS3ALDH1A1MEN1 | |
| SCHEMBL1285665 | 0.83 | GRIN2B (0.58) | NOS2NOS1RAB9ACYP2C19NPC1 | |
| SCHEMBL27092752 | 0.79 | POLB (0.63) | NOS2ALDH1A1L3MBTL1RAB9AMAPK1 | |
| SCHEMBL3063816 | 0.79 | ALDH1A1 (0.46) | NOS2NOS1ALDH1A1MEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL28775699 | 0.78 | ALDH1A1 (0.45) | NOS2NOS1ALDH1A1MEN1KMT2A | |
| SCHEMBL4564976 | 0.76 | SLC6A15 (0.44) | NOS2NOS1SLC6A15ALDH1A1MEN1 | |
| SCHEMBL13319027 | 0.73 | NOS2 (0.67) | NOS2NOS1NOS3ALDH1A1MEN1 | |
| SCHEMBL28652231 | 0.73 | ALDH1A1 (0.51) | NOS2NOS1NOS3ALDH1A1MEN1 | |
| SCHEMBL19873872 | 0.72 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2AL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176986-A1 | Process for the Preparation of Pyridine Heterocycle Cgrp Antagonist Intermediate | MERCK SHARP & DOHME CORP. | 2009-07-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176986-A1 | Process for the Preparation of Pyridine Heterocycle Cgrp Antagonist Intermediate | CCKBR, CALCRL, CALCR | NOS2 1245/4885NOS1 1282/4885SLC6A15 1158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.