Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11831465 | 0.86 | MEN1 (0.64) | MEN1KMT2AHTTP2RX3ADORA3 | |
| SCHEMBL4565974 | 0.80 | MEN1 (0.64) | MEN1KMT2ANPC1RAB9AADORA1 | |
| SCHEMBL27857171 | 0.77 | ADORA3 (0.63) | MEN1KMT2AHTTP2RX3ADORA3 | |
| SCHEMBL11832814 | 0.76 | PTPN1 (0.63) | MEN1KMT2AADORA3ABCG2NPC1 | |
| SCHEMBL3299661 | 0.74 | ADORA1 (0.70) | MEN1KMT2AADORA3JAK2TYK2 | |
| SCHEMBL26034951 | 0.71 | MEN1 (0.55) | MEN1KMT2AHTTP2RX3ADORA3 | |
| SCHEMBL821839 | 0.71 | KMT2A (1.00) | MEN1KMT2AADORA3NPC1RAB9A | |
| SCHEMBL4932652 | 0.70 | KDM4E (0.51) | MEN1KMT2AHTTNPC1RAB9A | |
| SCHEMBL3820618 | 0.70 | HTT (0.66) | MEN1KMT2AHTTADORA3NPC1 | |
| SCHEMBL27874235 | 0.70 | KDR (0.63) | MEN1KMT2ANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040048889-A1 | Use of non-competitive and selective glur5 antagonists as gultamate receptor modulating compounds | NEUROSEARCH A/S (DK) | 2004-03-11 | — | — | US | claimed |
| EP-1355640-A1 | USE OF NON-COMPETITIVE AND SELECTIVE GLUR5 ANTAGONISTS AS GLUTAMATE RECEPTOR MODULATING COMPOUNDS | NEUROSEARCH A/S (DK) | 2003-10-29 | — | — | EP | claimed |
| WO-2002058691-A1 | USE OF NON-COMPETITIVE AND SELECTIVE GLUR5 ANTAGONISTS AS GLUTAMATE RECEPTOR MODULATING COMPOUNDS | NEUROSEARCH A/S (DK) | 2002-08-01 | — | — | WO | claimed |
| US-7488756-B2 | Use of non-competitive and selective GluR5 antagonists as glutamate receptor modulating compounds | NEUROSEARCH A/S (DK) | 2009-02-10 | — | — | US | disclosed |
| US-20040048889-A1 | Use of non-competitive and selective glur5 antagonists as gultamate receptor modulating compounds | NEUROSEARCH A/S (DK) | 2004-03-11 | — | — | US | disclosed |
| EP-1355640-A1 | USE OF NON-COMPETITIVE AND SELECTIVE GLUR5 ANTAGONISTS AS GLUTAMATE RECEPTOR MODULATING COMPOUNDS | NEUROSEARCH A/S (DK) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002058691-A1 | USE OF NON-COMPETITIVE AND SELECTIVE GLUR5 ANTAGONISTS AS GLUTAMATE RECEPTOR MODULATING COMPOUNDS | NEUROSEARCH A/S (DK) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048889-A1 | Use of non-competitive and selective glur5 antagonists as gultamate receptor modulating compounds | GRM5, GRIK5, GRIN1 | MEN1 4791/4885KMT2A 1332/4885HTT 857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.