Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3446990 | 0.94 | ALDH1A1 (0.88) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL2342112 | 0.89 | KDM4E (0.62) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL2344193 | 0.81 | KDM4E (0.53) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL2481337 | 0.80 | LMNA (0.71) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL14564424 | 0.79 | ALDH1A1 (0.70) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL374154 | 0.75 | KDM4E (0.67) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL3918349 | 0.74 | LMNA (0.57) | ALDH1A1LMNAKDM4ENPC1 | |
| SCHEMBL2909352 | 0.74 | KDM4E (0.64) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL2350825 | 0.72 | LMNA (0.62) | ALDH1A1LMNAKDM4ESMN1; SMN2CYP2C9 | |
| SCHEMBL519334 | 0.72 | KDM4E (0.67) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034390-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |