Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 10/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16404602 | 0.71 | HTT (0.62) | GABRG2GABRB3GABRA5LMNATSHR | |
| SCHEMBL9557677 | 0.71 | NPC1 (0.41) | LMNAHTTCYP11B1CYP11B2 | |
| SCHEMBL693867 | 0.71 | TDP1 (0.36) | LMNATSHRHTTNPSR1CYP11B1 | |
| SCHEMBL699651 | 0.69 | TDP1 (0.41) | LMNATSHRHTTNPSR1CYP11B1 | |
| SCHEMBL7805166 | 0.67 | CYP11B1 (0.66) | LMNATSHRHTTNPSR1CYP11B1 | |
| SCHEMBL16736623 | 0.67 | MAPT (0.62) | GABRG2GABRB3GABRA5LMNATSHR | |
| SCHEMBL17678240 | 0.67 | GABRG2 (0.47) | GABRG2GABRB3GABRA5LMNATSHR | |
| SCHEMBL17678030 | 0.67 | GABRG2 (0.47) | GABRG2GABRB3GABRA5LMNATSHR | |
| SCHEMBL21883050 | 0.66 | HTT (0.72) | GABRG2GABRB3GABRA5LMNATSHR | |
| SCHEMBL4622510 | 0.66 | HTR6 (0.39) | LMNATSHRGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010526-A1 | BENZIMIDAZOLE 5-SULFONAMIDE DERIVATIVES AS CANNABINOID 1 (CB1) RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120101-A1 | BENZIMIDAZOLE 5-SULFONAMIDE DERIVATIVES AS CANNABINOID 1 (CB1) RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |