Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414806 | 0.79 | KMT2A (0.43) | ALDH1A1MEN1KMT2AHRH3KDM4E | |
| SCHEMBL25143661 | 0.74 | ALDH1A1 (0.52) | ALDH1A1MAPTL3MBTL1SMN1; SMN2HRH3 | |
| SCHEMBL2794284 | 0.72 | CACNA1B (0.52) | ALDH1A1MAPTPKMALOX12 | |
| SCHEMBL2796549 | 0.72 | MAPT (0.44) | ALDH1A1MAPTMEN1KMT2APKM | |
| SCHEMBL3327453 | 0.72 | L3MBTL1 (0.43) | ALDH1A1KMT2AL3MBTL1HRH3CNR2 | |
| SCHEMBL3327456 | 0.72 | L3MBTL1 (0.43) | ALDH1A1KMT2AL3MBTL1HRH3CNR2 | |
| SCHEMBL4418076 | 0.72 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AL3MBTL1RORC | |
| SCHEMBL2797076 | 0.70 | CACNA2D1 (0.40) | ALDH1A1MAPTPKMALOX12L3MBTL1 | |
| SCHEMBL10131854 | 0.69 | HPGD (0.54) | ALDH1A1PKMHRH3HPGD | |
| SCHEMBL2796408 | 0.69 | KCNH2 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061780-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2009-05-27 | — | — | EP | claimed |
| WO-2008031227-A1 | DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2008-03-20 | — | — | WO | claimed |