Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT2B7 | P16662 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.30 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414756 | 0.79 | PTPN1 (0.67) | UGT2B7PTPN1PTPN2PTPRCPTPN5 | |
| SCHEMBL4563376 | 0.77 | PTPN1 (0.43) | PTPN1PTPRC | |
| SCHEMBL3264596 | 0.76 | PTPN1 (0.46) | PTPN1PTPN2PTPRC | |
| SCHEMBL4566575 | 0.74 | PTPN1 (0.44) | PTPN1PTPN2PTPRC | |
| SCHEMBL2693268 | 0.73 | PTPN1 (0.47) | UGT2B7PTPN1PTPN2PTPRCCYP17A1 | |
| SCHEMBL18300941 | 0.72 | NOTUM (0.46) | UGT2B7CYP17A1CYP2C9CYP2C19PTPN5 | |
| SCHEMBL5610446 | 0.69 | UGT2B7 (0.82) | UGT2B7CYP17A1CYP2C9CYP2C19PLG | |
| SCHEMBL24779222 | 0.66 | UGT2B7 (0.64) | UGT2B7MMP9PLGPLAUAKR1C3 | |
| SCHEMBL30628955 | 0.66 | UGT2B7 (0.64) | UGT2B7MMP9PLGPLAUAKR1C3 | |
| SCHEMBL18562108 | 0.65 | UGT2B7 (0.62) | UGT2B7MMP9PLGPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114971-A1 | FUSED AROMATIC PTP-1B INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008089581-A1 | FUSED AROMATIC PTP-1B INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2008-07-31 | — | — | WO | disclosed |